Veraxanib was not genotoxic in a standard battery of in vitro and in vivo tests.
In repeat-dose toxicity studies up to 26 weeks in rats and dogs, the main findings were hyperphosphataemia, weight loss, and hepatocellular changes at exposures consistent with human therapeutic exposure. No carcinogenicity studies have been conducted with Veraxanib.
Reproductive and developmental toxicity studies in rats showed embryofoetal lethality and skeletal malformations at doses causing maternal toxicity. Effects on male fertility (reduced spermatogenesis) were observed at exposures approximately 2-fold above the human AUC at the recommended dose.
Veraxanib was phototoxic in an in vitro phototoxicity assay. The clinical relevance is unknown.
Veraxanib was not genotoxic in a standard battery of in vitro and in vivo tests.
In repeat-dose toxicity studies up to 26 weeks in rats and dogs, the main findings were hyperphosphataemia, weight loss, and hepatocellular changes at exposures consistent with human therapeutic exposure. No carcinogenicity studies have been conducted with Veraxanib.
Reproductive and developmental toxicity studies in rats showed embryofoetal lethality and skeletal malformations at doses causing maternal toxicity. Effects on male fertility (reduced spermatogenesis) were observed at exposures approximately 2-fold above the human AUC at the recommended dose.
Veraxanib was phototoxic in an in vitro phototoxicity assay. The clinical relevance is unknown.
Veraxanib was not genotoxic in a standard battery of in vitro and in vivo tests.
In repeat-dose toxicity studies up to 26 weeks in rats and dogs, the main findings were hyperphosphataemia, weight loss, and changes in the liver at exposures consistent with human therapeutic exposure.
Reproductive and developmental toxicity studies in rats showed embryofoetal lethality and skeletal malformations at doses causing maternal toxicity. Effects on male fertility (reduced spermatogenesis) were observed at exposures approximately 2-fold above the human AUC at the recommended dose.